For players that must attain the highest level the game may get sluggish. Explore farming in this region buy D2R ladder items. There's likely to be running stones and equipment that you get that will help, but the experience gain in this area is without challenge.
Nilathak's Temple a.k.a. Pindle Run (Act 5)In Act 5 the players don't need to go too far through Mount Arreat to get a ideal farming spot. The city of Harrogath already has one of the most frequently used grinding spots in the game. Nilathak's Temple is the ideal location, and players don't need to get the entire clearing of the area.
The person they're looking for is Pindleskin who's waiting for them at the front of the gate. Pindleskin's drop rate was nerfed however, he's still offering several very valuable treasure class items. Be aware that any player with a low level of life (less then 1,000) could be killed Pindleskin in a few swings.
Frosty Highlands (Act 5)Although there is no doubt that the world is mostly generated randomly one of the bosses always appears to be in the same place every time. Eldritch and his gang are common super-unique characters who remain just north of the line of sight every time Diablo 2 Resurrected buy items, making him a certain kill as well as the most straightforward victim to take on.